Computational drug design
نویسندگان
چکیده
منابع مشابه
Computational Drug Design and Small Molecule Library Design Computational Drug Design
Final Paper Computational Drug Design and Small Molecule Library Design Computational Drug Design In the past decade, significant investments in drug development have not translated into a parallel growth in new drugs [1]. Increasing knowledge and understanding of disease have expanded the number of therapeutic protein targets. However, few drug candidates targeting them reach the market as man...
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The need to account for the dynamic behavior of a receptor has long been recognized as a complicating factor in computational drug design. The use of a single, rigid protein structure—usually from a high-quality X-ray crystal structure— still is the standard in most applications (Zheng and Kyle, 1997; Walters et al., 1998). The choice to use a single protein structure is usually based on speed....
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 1999
ISSN: 1074-5521
DOI: 10.1016/s1074-5521(99)80093-3